Fever breaks. Some cats may show improvement in appetite and energy, however others will take longer. Effusion may continue to collect and increase for the first few days.
Favorable response to treatment is noticed for most cats within this time period. Ocular and neurological symptoms generally show improvement.
Dyspnea and associated thoracic effusion is typically resolved
Absorption of abdominal effusion begins to be noticed -- full resolution within 1-2 weeks. Ocular disease significantly or fully resolved.
Absorption of abdominal effusion is complete
Neurological symptoms typically show significant improvement within 24-72 hours, after which continued progress tends to be more gradual. Click here for a case report with video timeline showing resolution of paresis.
Hematological and serum chemistry changes
PCVs gradually return to normal levels about 6–8 weeks into treatment, with a transient dip in week 2.
Initial leukophilia (often neutrophilic) drops to normal levels within the first 2 weeks of treatment. Some cats experience neutropenia which may persist after treatment ends.
Lymphopenia often resolves after a week of treatment, with fluctuating lymphocyte levels throughout treatment. Some cats experience lymphocytosis, which may persist for several months after treatment ends.
Globulin levels rise during the first few weeks of treatment, with a dramatic rise in week 3, roughly corresponding with the timeframe when abdominal effusions are resolving.
Albumin levels typically start low and gradually rise throughout treatment.
No significant changes are seen in ALT, AST, ALP, lipase, amylase, BUN or creatinine levels are typically seen during treatment. A few cats (particularly older cats, or cats with already compromised kidneys) will see rising BUN, creatinine and SDMA values associated with GS-441524 treatment.